Content Types
Publications
- Early assessment of maternal bleeding: development and validation of a prognostic model predicting death and near miss
- Episiotomy and postpartum haemorrhage in women with moderate or severe anaemia: a cohort analysis of data from the WOMAN-2 trial
- The effects of anti-fibrinolytic drugs in patients with or at risk of bleeding: a protocol for a systematic review and individual patient data meta-analysis
- WHO recommendation on tranexamic acid for the treatment of postpartum haemorrhage – Highlights and Key Messages
- Red Blood Cell Transfusion and Mortality in Trauma Patients: Risk-Stratified Analysis of an Observational Study
- Differential effects of the Glasgow Coma Scale Score and its Components: An analysis of 54,069 patients with traumatic brain injury
- A nested mechanistic sub-study into the effect of tranexamic acid versus placebo on intracranial haemorrhage and cerebral ischaemia in isolated traumatic brain injury: study protocol for a randomised controlled trial (CRASH-3 Trial Intracranial Bleeding Mechanistic Sub-Study [CRASH-3 IBMS])
- A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan
- Cost-effectiveness analysis of tranexamic acid for the treatment of traumatic brain injury, based on the results of the CRASH-3 randomised trial: a decision modelling approach
- Accuracy of time to treatment estimates in the CRASH-3 clinical trial: impact on the trial results
- Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial
- Does tranexamic acid improve outcomes in traumatic brain injury?
- How effective is tranexamic acid for acute gastrointestinal bleeding?
- Risk factors for vascular occlusive events and death due to bleeding in trauma patients; an analysis of the CRASH-2 cohort
- Predicting early death in patients with traumatic bleeding: development and validation of prognostic model
- Implementation of tranexamic acid for bleeding trauma patients: a longitudinal and cross-sectional study
- Effect of consent rituals on mortality in emergency care research
- Antifibrinolytic therapy: new data and new concepts
- Tranexamic acid in trauma: we need stronger global health policy
- Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial
- Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms
- Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study)
- Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial
- Tranexamic acid for post-partum haemorrhage: What, who and when
- The effect of tranexamic acid on the risk of death and hysterectomy in women with post-partum haemorrhage: statistical analysis plan for the WOMAN trial
- Post-partum haemorrhage and tranexamic acid: a global issue
- Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial
- Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage
- Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials
- Pharmacokinetics of tranexamic acid after intravenous, intramuscular, and oral routes: a prospective, randomised, crossover trial in healthy volunteers
- WOMAN-PharmacoTXA trial: Study protocol for a randomised controlled trial to assess the pharmacokinetics and pharmacodynamics of intramuscular, intravenous and oral administration of tranexamic acid in women giving birth by caesarean section
- Tranexamic acid quantification in human whole blood using liquid samples or volumetric absorptive microsampling devices
- Clinical Validation of a Volumetric Absorptive Micro-Sampling Device for Pharmacokinetic Studies With Tranexamic Acid
- Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review
- Tranexamic acid by the intramuscular or intravenous route for the prevention of postpartum haemorrhage in women at increased risk: a randomised placebo-controlled trial (I’M WOMAN)
- Outcome measures in clinical trials of treatments for acute severe haemorrhage
- Extending evidence for the use of tranexamic acid from traumatic haemorrhage to other patients with major bleeding: do we need more than one haemorrhage protocol? The case of gastrointestinal bleeding
- Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial
- Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial
- The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury
- Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial
- Barriers and facilitators to the administration of prehospital tranexamic acid: a paramedic interview study using the theoretical domains framework
- A cost-effectiveness and value of information analysis to inform future research of tranexamic acid for older adults experiencing mild traumatic brain injury
- Use of tranexamic acid in major trauma: a sex-disaggregated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2 and CRASH-3) trials and UK trauma registry (Trauma and Audit Research Network) data
- Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial
- Decolonising knowledge production: our experience researching tranexamic acid for trauma victims
- Applying results from clinical trials: tranexamic acid in trauma patients
- Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
- Bringing women to the forefront of science and medicine
- Cost-Effectiveness Analysis of Administering Tranexamic Acid to Bleeding Trauma Patients Using Evidence from the CRASH-2 Trial
- Obituary – Utako Okamoto
- Offline: A story of discrimination against women
- A promise to save 100,000 trauma patients
- Tranexamic acid for trauma in the USA: is prejudice a barrier to saving lives?
- Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
- The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial
- The CRASH trial protocol (Corticosteroid randomisation after significant head injury) [ISRCTN74459797]
- Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial
- Finding Better Ways to Prevent Postpartum Hemorrhage
- Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
- Anti-fibrinolytic agents in post partum haemorrhage: a systematic review
- The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries
- Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials
- The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial
- Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial
- Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40138 bleeding patients
- Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial): a randomised trial and pharmacological study in caesarean section births
- Tranexamic acid for the prevention of postpartum bleeding: Protocol for a systematic review and individual patient data meta-analysis
- Postpartum haemorrhage in anaemic women: assessing outcome measures for clinical trials
- Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: study protocol for an international, randomised, double-blind, placebo-controlled trial
- Maternal anaemia and the risk of postpartum haemorrhage: a cohort analysis of data from the WOMAN-2 trial
- The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial
- Tranexamic acid for postpartum bleeding: a systematic review and individual patient data meta-analysis of randomised controlled trials
